6 edition of Iminosugars found in the catalog.
Includes bibliographical references and index.
|Statement||edited by Philippe Compain and Olivier R. Martin.|
|Contributions||Compain, Philippe., Martin, Olivier R.|
|LC Classifications||QP702.I45 I45 2007|
|The Physical Object|
|LC Control Number||2007023155|
Authors contributing to RSC publications journal articles, books or book chapters do not need to formally request permission to reproduce material contained in this article provided that the correct acknowledgement is given with the reproduced material. Jenkinson, J. Brand new Book. Kato, I. Iminosugars The iminosugars are a widespread group of plant and microbial compounds that are attracting interest as therapeutic agents due to their ability to interact with human glycosidases, other proteins and sugar receptors [ 1 ].
Future Med. The final prices may differ from the prices shown due to specifics of VAT rules About this book This volume is devoted to compounds in which the spiro centre is part of a pyranoid or furanoid or an iminosugar ring. Fleet and S. Condition: New.
Moving closer to therapeutic applications, chapters 9 and 12 are devoted to iminosugars as antiviral and antitumor agents respectively. Martin univ-orelans. While monosaccharides per se appear as heterocycles, their natural conjugates frequently exhibit spiro hetero cyclic derivatives, in many cases of high therapeutical relevance. The impressive series of discoveries in the field over the past ten years indicates clearly that it is "a boom time" for iminosugar chemistry and biology.
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Filer, J. Compounds have been selected for Iminosugars book potential as therapeutic agents. Future Med Chem. Future Med. The bicyclic structures may biologically resemble disaccharides. Very few iminosugars have been available up to now for evaluation of their pharmaceutical applications.
The chapters contributed deal with methodological peculiarities of syntheses of natural and artificial sugar derived spirocycles as well as their biological applications and other utilities including marketed drugs. The final prices may differ from the prices shown due to specifics of VAT rules About this book This volume is devoted to compounds in which the spiro centre is part of a pyranoid or furanoid or an iminosugar ring.
As a consequence, the field of carbohydrate-spiro-heterocycles attracts intense interest from both chemical and biomedical aspects therefore this volume will be of interest for synthetic and medicinal chemists and glyco Iminosugars book, as well as researchers involved in various biomedical fields.
Carbohydrates are ubiquitous molecules in nature and participate in a vast number of biological interactions. The scope of their profile as inhibitors has been extended to a number of enzymes such as phosphorylases, glycosyltransferases or metalloproteinases, and iminosugars now constitute lead compounds for the development of new therapeutic agents for a wide range of diseases including diabetes, viral infections, lysosomal storage disorders and tumor metastasis.
Latest developments, from iminosugar synthesis to their use in clinical studies, are presented in this book, which contains contributions from over fifteen of the major chemists, biochemists and drug developers in this rapidly expanding field.
His research interests include synthetic carbohydrate chemistry directed to C-glycosyl compounds, anomeric-spirocycles, glycals, exo-glycals and their derivatives; development of synthetic methodology involving radicals and carbenes; synthesis of glycosidase and glycogen phosphorylase inhibitors as potential antidiabetics, study of their structure-activity relationships; synthesis of glycomimetics and glycopeptidomimetics.
Jenkinson, J. Finally, chapter 14 provides tables which correlate the structure of more than iminosugars of therapeutic interest with their biological activities. The aim of this book is to present the multifaceted aspects of iminosugars from structure to biological activities and from synthesis to therapeutic applications.
The 1-deoxy analogs of iminosugars are C-glycosideswith the nitrogen as part of an ordinary amine linkage. Information about reproducing material from RSC articles with different licences is available on our Permission Requests page. Although the natural products from plants and microorganisms can have good specificity, modifications of the template natural products have been very successful recently in producing bioactive compounds with good profiles.
Jump to navigation Jump to search The chemical structure of 1-deoxynojirimycinan example of a simple iminosugar.
The field of iminosugars continues to open up exciting new opportunities for therapeutic agent discovery and offers many new tools for precisely modifying carbohydrate structures and modulating glycosidase activity in vivo.
Chapter 13 is an overview of the medicinal use of iminosugars, including key reflections on their therapeutic potential. Other therapeutic applications are under investigations, for example for the treatment of certain forms of cancer, of Fabry disease and viral infections hepatitis B.
Since the discovery of this first generation, many new natural products have been identified with a wide range of biological activities but few are widely available. Prod: Book Review of Iminosugars: From Synthesis to Therapeutic ApplicationsCited by: 1.
Feb 16, · Abstract. From their discovery in the late s, iminosugars have undergone an expansion from an area of science limited to a few researchers to a field that now attracts the interest of members of the whole synthetic organic chemistry atlasbowling.com: Damien Hazelard, Raphaël Hensienne, Jean-Bernard Behr, Philippe Compain.
Get this from a library! Iminosugars: from synthesis to therapeutic applications. [Philippe Compain; Olivier R Martin;] -- Iminosugars are becoming important lead compounds for drug development in a variety of therapeutic areas, including diabetes, viral infections and tumour metastasis.
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The compound was named nojirimycin. Whereas this compound was shown in to exhibit modest antibiotic activities, the properties of iminosugars as powerful glycosidase inhibitors were discovered only many years later () by chemists at atlasbowling.com by: RETURN TO ISSUE PREV Book Review NEXT.
Book Review of Iminosugars: From Synthesis to Therapeutic Applications. Crist N. Filer; View Author Information. PerkinElmer Life and Analytical Sciences Albany StreetBoston, Massachusetts Cited by: 1.
Iminosugars as therapeutic agents: recent advances and promising trends. Nash RJ(1), Kato A, Yu CY, Fleet GW. Author information: (1)Phytoquest Limited, Plas Gogerddan, Aberystwyth, Ceredigion SY23 3EB, UK. [email protected] For the purpose of this article, iminosugars are polyhydroxylated secondary and tertiary amines in which the Cited by: